APoGI for the Haemoglobin Disorders

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Implications for a Child when One Partner carries Haemoglobin C and the Other carries Hereditary Persistence of Fetal Haemoglobin (HPFH)

There is no particular problem for this couple, because this combination cannot cause an inherited anaemia in their children.

Partner who carries haemoglobin C			Partner who carries HPFH

Not a carrier	Carrier of haemoglobin C	Carrier of HPFH	Child who carries both haemoglobin C and HPFH

In each pregnancy, there are four possibilities:

The child may not carry any haemoglobin disorder.
The child may carry Haemoglobin C. This is harmless.
The child may carry HPFH. This is harmless.
The child may inherit haemoglobin C from one parent and HPFH from the other. This is harmless.

This couple has the same chance of a healthy family as other couples do.

When the children grow up...

... they should have blood test to see if they have inherited haemoglobin C or HPFH. If they have, their partner should have a test "for haemoglobin disorders". It is important to remember this for the future.

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These documents are part of the APoGI May 1998 (Evaluation) Release and are made available subject to the APoGI Disclaimers covering usage, distribution and copying.

Problems or further enquiries to APoGI@chime.ucl.ac.uk or the APoGI Contacts