Title: GENETIC RISK FOR A CARRIER OF ALPHA PLUS THALASSAEMIA, WHOSE PARTNER CARRIES HEREDITARY PERSISTENCE OF FETAL HAEMOGLOBIN (HPFH)
Author: Mary Petrou
Last saved by: Matthew Darlison

Implications for a Child when One Partner carries Alpha Zero Thalassaemia and the Other carries Hereditary Persistence of Fetal Haemoglobin (HPFH)
There is no particular problem for this couple. This combination cannot cause an inherited anaemia in their children.

In each pregnancy, there are four possibilities:
•	The child may not carry any haemoglobin disorder.
•	The child may carry alpha zero thalassaemia. This is harmless.
•	The child may carry HPFH. This is harmless.
•	The child may inherit alpha zero thalassaemia from one parent and HPFH from the other. This is harmless.
This couple has the same chance of a healthy family as other couples.
When the children grow up, they should have blood test to see if they have inherited alpha zero thalassaemia or HPFH. If they have, their partner should have a test "for haemoglobin disorders". It is important to remember this for the future.
For more information about carrying haemoglobin disorders contact: